متغیرهای مرد نسبت به تنوع زنان در ساختار مغز منطقه ای (مقاله)

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View ORCID ProfileLara MWierenga,View ORCID ProfileGaelle EDoucet,DanaiDima,View ORCID ProfileIngridAgartz,MojiAghajani,Theophilus NAkudjedu,AntonAlbajes-Eizagirre,View ORCID ProfileDagAlnæs,Kathryn IAlpert,Ole AAndreassen,AlanAnticevic,PhilipAsherson,TobiasBanaschewski,NuriaBargallo,SarahBaumeister,RamonaBaur-Streubel,AlessandroBertolino,AuroraBonvino,View ORCID ProfileDorret IBoomsma,StefanBorgwardt,JosianeBourque,Anoukden Braber,DanielBrandeis,AlanBreier,HenryBrodaty,Rachel MBrouwer,Geraldo FBusatto,Vince DCalhoun,Erick JCanales-Rodríguez,Dara MCannon,XavierCaseras,Tiffany MChaim-Avancini,Christopher RKChing,Patricia JConrod,AnnetteConzelmann,FabriceCrivello,Christopher GDavey,Erin WDickie,StefanEhrlich,Dennisvan’t Ent,Jean-PaulFouche,PaolaFuentes-Claramonte,Eco JCde Geus,AnnabellaDi Giorgio,David CGlahn,Ian HGotlib,View ORCID ProfileHans JGrabe,OliverGruber,PatriciaGruner,Raquel EGur,Ruben CGur,View ORCID ProfileTiril PGurholt,Lieuwede Haan,BeatheHaatveit,Ben JHarrison,View ORCID ProfileSean NHatton,Odile Avan den Heuvel,Ian BHickie,SarahHohmann,View ORCID ProfileAvram JHolmes,MartineHoogman,NorbertHosten,Fleur MHowells,Hilleke EHulshoff Pol,ChaimHuyser,NedaJahanshad,Anthony CJames,Erik GJönsson,John AJoska,Karolinska Schizophrenia Project (KaSP) Consortium,MariekeKlein,LauraKoenders,Knut KKolskår,BerndKrämer,JonnaKuntsi,JimLagopoulos,LuisaLazaro,Irina SLebedeva,Phil HLee,ChristineLochner,Marise WJMachielsen,SophieMaingault,Nicholas GMartin,IgnacioMartínez-Zalacaín,DavidMataix-Cols,BernardMazoyer,Brenna CMcDonald,ColmMcDonald,View ORCID ProfileAndrew MMcIntosh,Katie LMcMahon,GenevieveMcPhilemy,Dennisvan der Meer,José MMenchón,JillyNaaijen,LarsNyberg,View ORCID ProfileYannisPaloyelis,PaulPauli,GiulioPergola,EdithPomarol-Clotet,Maria JPortella,JoaquimRadua,AndreasReif,View ORCID ProfileGenevièveRichard,Joshua LRoffman,Pedro GPRosa,Matthew DSacchet,View ORCID ProfilePerminder SSachdev,RaymondSalvador,SalvadorSarró,Theodore DSatterthwaite,View ORCID ProfileAndrew JSaykin,Mauricio HSerpa,KangSim,AndrewSimmons,Jordan WSmoller,Iris ESommer,CarlesSoriano-Mas,Dan JStein,Lachlan TStrike,Philip RSzeszko,Henk STemmingh,Sophia IThomopoulos,Alexander STomyshev,Julian NTrollor,AnneUhlmann,Ilya MVeer,Dick JVeltman,AristotleVoineskos,HenryVölzke,HenrikWalter,LeiWang,View ORCID ProfileYangWang,View ORCID ProfileBerndWeber,WeiWen,John DWest,View ORCID ProfileLars TWestlye,Heather CWhalley,Steven CRWilliams,KatharinaWittfeld,Daniel HWolf,Margaret JWright,Yuliya NYoncheva,Marcus VZanetti,Georg CZiegler,Greig Ide Zubicaray,View ORCID ProfilePaul MThompson,Eveline ACrone,SophiaFrangou,Christian KTamnes

doi:https://doi.org/10.1101/2020.02.17.952010

Abstract

For many traits, males show greater variability than females, with possible implications for understanding sex differences in health and disease. Here, the ENIGMA (Enhancing Neuro Imaging Genetics through Meta-Analysis) Consortium presents the largest-ever mega-analysis of sex differences in variability of brain structure, based on international data spanning nine decades of life. Subcortical volumes, cortical surface area and cortical thickness were assessed in MRI data of 16,683 healthy individuals 1-90 years old (47% females). We observed patterns of greater male than female between-subject variance for all brain measures. This pattern was stable across the lifespan for 50% of the subcortical structures, 70% of the regional area measures, and nearly all regions for thickness. Our findings that these sex differences are present in childhood implicate early life genetic or gene-environment interaction mechanisms. The findings highlight the importance of individual differences within the sexes, that may underpin sex-specific vulnerability to disorders.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity.It is made available under aCC-BY-NC-ND 4.0 International license.

 

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